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■ Synthesis of Novel Benzimidazole and Benzothiazole Derivatives

Ahmed F. Darweesh, Ahmed E. M. Mekky, Amani A. Salman, and Ahmad M. Farag*

*Department of Chemistry, Faculty of Science, Cairo University, Giza 12013, Egypt

Abstract

1-(Benzothiazol-2-yl)-2-phenylsulfonyl-1-ethanone (1) and 1-(1-methyl-1H-benzimidazol-2-yl)-2-(phenylsulfonyl)-1-ethanone (2) were used as potential scaffolds for biologically interesting azoloazine derivatives via their reaction with the diazonium salts of 5-aminopyrazole, 5-amino[1,2,4]triazole and 2-aminobenzimidazole. Coupling of the β-ketosulfones 1 or 2 with diazotized aromatic amines afforded the corresponding arylhydrazone derivatives which have been utilized as versatile building blocks for the synthesis of biologically interesting pyridazine ring systems.