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Short Paper | Regular issue | Vol 89, No. 1, 2014, pp.189-196
Published online, 29th November, 2013
DOI: 10.3987/COM-13-12874
Novel Cytotoxic Metabolites from the Marine-Derived Fungus Trichoderma citrinoviride

Xiao Hu, Mei-Wei Gong, Wei-Wei Zhang, Qiu-Hong Zheng, Qin-Ying Liu, Li Chen,* and Qi-Qing Zhang*

*College of Chemistry and Chemical Engineering, Institute of Biomedical and Pharmaceutical Technology , Fuzhou University, No. 523, Gongye Road, Fuzhou City, 350002, China

Abstract

Three new compounds, trichoderiol C (1), citrinoviric acid (4), and penicillenol D (5), together with seven known compounds, trichoderiol A (2), lignoren (3), penicillenol B1 (6), penicillenol B2 (7), cyclo-(Leu-Pro) (8), cyclo-(Ile-Pro) (9), and cyclo-(Phe-Pro) (10), were isolated from the marine-derived fungus Trichoderma citrinoviride. The structures of these compounds were elucidated using spectroscopic methods, including 1D and 2D nuclear magnetic resonance and high-resolution mass spectrometric analyses. Among these compounds, 4 and 5 showed moderate cytotoxic effects on the A-375 cell line, with IC50 values of 85.7 and 32.6 μM, respectively.