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Short Paper | Regular issue | Vol 89, No. 2, 2014, pp.481-486
Published online, 20th December, 2013
DOI: 10.3987/COM-13-12889
Anthraquinones from Cassia fistula and Their Anti-Tobacco Mosaic Virus Activity

Yin-Ke Li, Yu-Chun Yang, Ying Qin, Yanlin Meng, Yan-Qing Ye, Hai-Ying Yang, Xue-Mei Gao,* and Qiu-Fen Hu*

*Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming, Jingming South Road, Chenggong New District, Kunming, Yunnan 650500, China


Two new anthraquinones, 9,11-dihydroxy-2-(hydroxymethyl)-5-methyl-4H-naphtho[2,3-h]chromene-4,7,12-trione (1) and 9,11-dihydroxy-2,5-dimethyl-4H-naphtho[2,3-h]chromene-4,7,12-trione (2), together with five known anthraquinones (3-7) were isolated from the stems of Cassia fistula. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D NMR techniques. Compounds 1-7 were tested for their anti-tobacco mosaic virus activity. The results showed that compound 7 exhibited high anti-TMV activity with inhibition rate of 35.2%. The inhibition rate is high than that of positive control. The other compounds also showed potential anti-TMV activities with inhibition rates in the range of 15.2 –24.8%, respectively.