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Short Paper | Regular issue | Vol 89, No. 4, 2014, pp.1017-1024
Published online, 18th February, 2014
DOI: 10.3987/COM-13-12920
Improving the Synthesis of Spiropyran Derivatives Using Microwave Irradiation Method

Atisya Rohadi, Siti Aishah Hasbullah,* Azwan Mat Lazim, and Rumaisa Nordin

*School of Chemical Sciences and Food Technology, Food Science and Chemical Technology, Faculty of Science and Technology , The National University of Malaysia, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia


A solvent free synthesis of spiropyran derivatives has been developed from the condensation of indoline and salicylaldehyde using a microwave irradiation method. This method starts from readily available starting materials and provides biologically interesting products. The microwave irradiation method was remarkably successful and gave spiropyran derivatives in higher yield (72–99%) with a much shorter reaction time (10–15 min) compared to the conventional heating method. The chemical structures of the compounds prepared were characterized through IR, 1H NMR and 13C NMR spectral data.