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Short Paper | Regular issue | Vol 89, No. 4, 2014, pp.1035-1040
Published online, 6th March, 2014
DOI: 10.3987/COM-14-12933
Expeditious Synthesis of Ivacaftor

Yang He, Qien Xu, Wenpeng Ma, Jian Zhang, Hongbing Sun, and Jingshan Shen*

*Chinese Academy of Sciences, Shanghai Institute of Materia Medica, 555 Zuchongzhi Rd., Zhangjiang Hi-Tech Park, Shanghai, 201203, China


An expeditious synthesis for Ivacaftor featuring modified Leimgruber-Batcho procedure was described. The overall yield is 39% over six steps from commercially available 2-nitrobenzoyl chloride.