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Short Paper | Regular issue | Vol 89, No. 5, 2014, pp.1229-1236
Published online, 18th March, 2014
DOI: 10.3987/COM-14-12966
Synthesis of 2-Arylbenzimidazole Analogues

Meng-Yang Chang,* Chieh-Kai Chan, and Yi-Chia Chen

*Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, TaiwanNo. 100, Shih-Chuan 1st Rd., San Ming District, Kaohsiung 80708, Taiwan, R.O.C.


Substituted 2-arylbenzimidazoles (4) were easily synthesized in good yields starting from the condensation reaction of 1,2-diaminobenzenes (1) with β-ketosulfones (5) in the presence of boiling HOAc.