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Short Paper | Regular issue | Vol 89, No. 5, 2014, pp.1255-1259
Published online, 27th March, 2014
DOI: 10.3987/COM-14-12974
Isoindolone Synthesis via Intramolecular Coupling of Benzylic C-H Bonds with Amide N-H Bonds

Ming Zhang,* Tianbao Chen, and Qinhua Liu

*College of Chemistry, Jiangxi Normal University, 99 Ziyangdadao, Nanchang, Jiangxi, 330022 , China

Abstract

Four 7-methyl-2-(8-quinolinyl)-2,3-dihydro-1H-isoindol-1-ones were synthesized from 2,6-dimethyl-N-(8-quinolinyl)benzamides with exellent yields using Pd(OAc)2 as a catalyst, iodobenzene as an oxidant and AgOAc as an additive.