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Short Paper | Regular issue | Vol 89, No. 7, 2014, pp.1656-1661
Published online, 30th May, 2014
DOI: 10.3987/COM-14-13001
A New Dihydrooxazole Antibiotic from the Fermentation Broth of Streptomyces djakartensis

Ji-Wen Zhang, Wen-Juan Zhang, Shao-Peng Wei, and Wen-Jun Wu*

*College of Science, Northwest A&F University, Yangling 712100, Shaanxi Province, China

Abstract

A new antibiotic was isolated from the fermentation broth of Streptomyces djakartensis by bioassay-guided fractionation. It was elucidated as (S)-2-(2-hydroxyphenyl)-4-hydroxymethyl-4,5-dihydrooxazole mainly by analyses of 2D NMR and MS spectral data and the absolute configuration of the antibiotic was established by X-ray crystal data. It exhibited broad spectrum antibacterial activities with MIC values of 7.81~31.25 μg/mL.