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Short Paper | Regular issue | Vol 89, No. 6, 2014, pp.1473-1482
Published online, 25th April, 2014
DOI: 10.3987/COM-14-12979
A Convenient Synthetic Method of Isoxazole Derivatives Using Copper(II) Nitrate

Ken-ichi Itoh,* Tadashi Aoyama, Hiroaki Satoh, Kenta Hasegawa, Natsumi Meguro, Akira C. Horiuchi, Toshio Takido, and Mitsuo Kodomari

*Department of Liberal Arts and Science, College of Science and Technology, Nihon University, 7-24-1 Narashinodai, Funabashi-shi, Chiba 274-8501, Japan

Abstract

3-Acetylisoxazoles were synthesized by the reaction of alkenes or alkynes in acetone as solvent with copper(II) nitrate and formic acid. In the case of ethyl acetate as solvent, 3-benzoylisoxazoles were yielded by the reaction of alkynes and acetophenone with copper(II) nitrate and nitric acid. This synthetic method provides a convenient production of isoxazole derivatives.