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Review | Regular issue | Vol 89, No. 8, 2014, pp.1767-1800
Published online, 22nd May, 2014
DOI: 10.3987/REV-14-796
Asymmetric Synthesis of Cyclopropylamine Derivatives

Han Wang, Xiaokun Zhou, and Yongjun Mao*

*Department of Medicinal Chemistry, Shanghai University of Engineering Science, 333 Longteng Rd., Songjiang, Shanghai, 201620, China

Abstract

Cyclopropylamines are important synthetic intermediates and their enantiopure forms are also useful as chiral resolving agents. The present review outlines the recent developments on the asymmetric synthesis of cyclopropylamine derivatives. The transformations based on carbene or carbenoid species, asymmetric catalysis, ylide formation, Simmons-Smith, Kulinkovich and Mitsunobu reaction, conjugate addition, Favorskii-type rearrangement and intramolecular cyclopropanations are elaborated.