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Paper | Special issue | Vol 90, No. 1, 2015, pp.357-371
Published online, 10th June, 2014
DOI: 10.3987/COM-14-S(K)26
Design and Synthesis of Conformationally Constrained Bicyclo[2.2.2]octane-Based Unusual α-Amino Acid Derivatives via the Diels–Alder Reaction

Sambasivarao Kotha* and Milind Meshram

*Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai - 400076, India

Abstract

We report a simple synthetic approach to various conformationally constrained bicyclic α-amino acid derivatives using the DielsAlder reaction as a key step. Moreover, we have investigated the reactivity pattern of various anthracene derivatives in relation to the DielsAlder chemistry.