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Paper | Special issue | Vol 90, No. 1, 2015, pp.425-431
Published online, 30th June, 2014
DOI: 10.3987/COM-14-S(K)38
2-Debromonagelamide U, 2-Debromomukanadin G, and 2-Debromonagelamide P from Marine Sponge Agelas sp.

Kenta Nakamura, Taishi Kusama, Naonobu Tanaka, Kanae Sakai, Tohru Gonoi, Jane Fromont, and Jun'ichi Kobayashi*

*Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo, Hokkaido 060-0812, Japan

Abstract

Two new monomeric bromopyrrole alkaloids (1 and 2) and one new dimeric bromopyrrole alkaloid (3) were isolated from an Okinawan marine sponge Agelas sp. Spectroscopic analyses of these compounds revealed the structures of 13 to be 2-debromonagelamide U, 2-debromomukanadin G, and 2-debromonagelamide P, respectively. Antimicrobial activity of 13 was evaluated.