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Short Paper | Regular issue | Vol 89, No. 8, 2014, pp.1913-1922
Published online, 7th July, 2014
DOI: 10.3987/COM-14-13035
A New Cyclic Triterpene Saponin from Phyteuma japonicum

Chung Sub Kim, Oh Wook Kwon, Sun Yeou Kim, Ki Hyun Kim, and Kang Ro Lee*

*Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 300 Chunchun-dong, Jangan-ku, Suwon 440-746, Korea

Abstract

A new cyclic triterpene saponin, phyteujaposide (1) and eight known compounds (2-9) were isolated from the leaves of Phyteuma japonicum. The structure of the new compound (1) was elucidated by 1D and 2D data analysis, acid hydrolysis and GC-MS. Compounds 7 and 9 potently inhibited the NO production in LPS-activated BV-2 cells and compounds 5 and 6 showed a significant secretion induction of NGF in C6 glioma without cell toxicity.