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Paper | Special issue | Vol 90, No. 2, 2015, pp.967-977
Published online, 4th August, 2014
DOI: 10.3987/COM-14-S(K)64
Catalytic and Enantioselective Synthesis of a Key Intermediate of the MCHr1 Antagonist AMG 076

Shinji Harada, Haruka Ishii, Daisuke Shirasaki, and Atsushi Nishida*

*Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, Japan


A chiral decahydroisoquinoline was constructed using our asymmetric Diels-Alder reaction catalyzed by a chiral Yb (ytterbium) complex as a key step. The decahydroisoquinoline is a synthetic intermediate of the anti-obesity drug candidate AMG 076 (Amgen).