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■ Phenyl Derivated Butyrolactones from the Fermentation Products of an Endophytic Fungus Aspergillus terreus

Yan-Qing Ye, Cong-Fang Xia, Juan-Xia Yang, Yu-Chun Yang, Xue-Mei Gao, Gang Du, Hai-Ying Yang, Xue-Mei Li,* and Qiu-Fen Hu*

*Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming, Jingming South Road, Chenggong New District, Kunming, Yunnan 650500, China

Abstract

Two new phenyl derivated butyrolactones, terrephenols A and B (1 and 2), together with four known butyrolactones (3-6) were isolated from the fermentation products of a fungus Aspergillus terreus. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D- NMR techniques. The anti-tobacco mosaic virus (anti-TMV) activities of 1-6 were evaluated. Compounds 1 and 2 showed high anti-TMV activities with inhibition rates of 35.2% and 31.0 %, and 3-6 showed modest anti-TMV activity with inhibition rates of 15.4-24.6%, respectively. Compounds 1 and 2 were also tested for their cytotoxicities. 1 showed high cytotoxicity against A549 and MCF7 cell with IC50 values of 4.2 and 3.6 μM, and 2 showed high cytotoxicity against A549 and MCF7 cell with IC50 values of 3.9 and 4.8 μM, respectively.