Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,320 (Yen only)
Period: This Article can be accessed for 7 days.

Short Paper | Regular issue | Vol 89, No. 10, 2014, pp.2375-2379
Published online, 3rd October, 2014
DOI: 10.3987/COM-14-13069
Cytotoxicity Flavones from Desmodium oxyphyllum

Xue-Mei Gao, Huang Wang, Yin-Ke Li, Bing-Kun Ji, Cong-Fang Xia, Juan-Xia Yang, Ming Zhou, Yan-Qing Ye, and Qiu-Fen Hu*

*Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming, Jingming South Road, Chenggong New District, Kunming, Yunnan 650500, China

Abstract

Two new flavones, oxyphyllumflavone A and B (1 and 2) were isolated from Desmodium oxyphyllum. Their structures were elucidated by spectroscopic methods including extensive 1D- and 2D-NMR techniques. Compounds 1 and 2 are the first naturally occurring flavones possessing a six-membered 6-methyl-α-pyrone ring. Compounds 1 and 2 were also evaluated for their cytotoxicity against NB4, A549, SHSY5Y, PC3, and MCF7 cell lines, and they showed cytotoxicity with IC50 values in the range of 4.2 – 9.6 μM.