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Review | Regular issue | Vol 89, No. 11, 2014, pp.2479-2543
Published online, 30th October, 2014
DOI: 10.3987/REV-14-808
Transition Metal-Mediated Synthesis of Oxazoles

Stefano Bresciani and Nicholas C. O. Tomkinson*

*Department of Pure and Applied Chemistry, University of Strathclyde, Thomas Graham Building, 295 Cathedral Street, Glasgow, G1 1XL, U.K.

Abstract

Among the synthetic methods for the formation of the oxazole ring, transition metal-mediated protocols are the most attractive in terms of selectivity, efficiency and mildness of reaction conditions. In this review we discuss methods for the preparation of oxazoles using transition metal complexes highlighting the key bonds being formed. This reveals critical gaps in the existing literature for the construction of this biologically significant ring system highlighting exciting opportunities for further research.