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Short Paper | Regular issue | Vol 91, No. 5, 2015, pp.1001-1006
Published online, 6th April, 2015
DOI: 10.3987/COM-14-13140
Palladium-Catalyzed Suzuki Coupling towards 2-Amino-1,8-naphthyridines

Hangming Ge and Qiancai Liu*

*School of Chemistry and Molecular Engineering,, East China Normal University, Shanghai 200241, China


Several 2-amino-6-aryl-1,8-naphthyridines were reported. The cyclocondensation of 2,6-diaminopyridine, 2-bromomalonaldehyde in phosphoric acid resulted in the formation of 2-amino-6-bromo-1,8-naphthyridine, which was converted into 2-amino-6-aryl-1,8-naphthyridines by palladium-catalyzed Suzuki reaction with arylboronic acid. It is shown that the Suzuki coupling with palladium catalyst (Pd-132) could be completed efficiently with lower catalyst loading and good to excellent yields. The title compounds were characterized by NMR spectra and mass spectra.