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Short Paper | Regular issue | Vol 91, No. 6, 2015, pp.1187-1197
Published online, 11th May, 2015
DOI: 10.3987/COM-15-13175
Triterpene Saponins from the Aerial Parts of Ilex cornuta and Their Cytotoxic Activity

Seung Young Lee, Won Se Suh, Ho Kyung Kim, Il Kyun Lee, Sang Un Choi, Ki Hyun Kim, and Kang Ro Lee*

*Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 300 Chunchun-dong, Jangan-ku, Suwon 440-746, Korea

Abstract

Four new triterpene saponins (1-4), together with 13 known triterpenoids (5-17), were isolated from the MeOH extract of Ilex cornuta Lindley (Aquifoliaceae). Their structures were elucidated on the basis of chemical and spectroscopic methods. The isolated compounds were tested for their cytotoxicities against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15) in vitro using the sulforhodamine B (SRB) assay.