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Short Paper | Regular issue | Vol 91, No. 6, 2015, pp.1198-1203
Published online, 28th May, 2015
DOI: 10.3987/COM-15-13190
Flavonoids from the Leaves of Sun Cured Tobacco and their Anti-Tobacco Mosaic Virus Activity

Yun Wang, Chun-Bo Liu, Qin-Peng Shen, Feng-Mei Zhang, Pei He, Zhi-Hua Liu, Hong-Bin Zhang, Xiao-Dong Yang, Ming-Ming Miao,* and Guang-Yu Yang*

*Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industry Company, Hongjin Road 181#, Kunming, 650231, China

Abstract

Two new flavonoids, 4',6-dihydroxy-7,8-dimethoxyisoflavone (1), 8-acetyl-4'-hydroxy-7-methoxy-6-methylflavone (2), together with four known flavonoids (3-6) were isolated from the leaves of Yunnan local sun cured tobacco. Their structures were determined by means of HRESIMS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1-6 were tested for their anti-tobacco mosaic virus (anti-TMV) activities. Compound 2 showed high anti-TMV activity with inhibition rate of 35.4%. This rate is higher than that of positive control. The other compounds also showed potential anti-TMV activity with inhibition rates in the ranges of 18.5-22.3%, respectively.