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■ New Anti-Oxidative Compounds from Rhinacanthus Nasutus

Ryuichiro Suzuki, Hiroshi Sakagami, and Yoshiaki Shirataki*

*Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan

Abstract

Two new antioxidative compounds were isolated from methanolic extract of root of the Rhinacanthus nasutus. These chemical structures were elucidated by analysis of 1D and 2D NMR spectra including MS. Antioxidant activities of these isolates were determined by DPPH radical scavenging activity test. As the results, antioxidant activities of these isolates were comparative to Trolox used as a positive control. These isolates showed little or no detectable cytotoxicity against both human cancerous and normal cells.