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■ CoCl2•6H2O-Promoted Pinner-Dimroth Tandem Reaction: Facile Synthesis of 3-Substituted Isoindolinones

Mingxing Liu, Jiarong Li, Qi Zhang, and Daxin Shi*

*Department of Chemical Engineering, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing Postcode: 100081, China

Abstract

A convenient one-pot synthesis of 3-substituted isoindolinones were reported in good yield via Pinner-Dimroth tandem reaction of 1,3-dicarbonyl compounds and 2-cyanobenzaldehyde in the catalysis of CoCl2•6H2O. This method has advantages of time efficiency and mild reaction conditions.