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Short Paper | Special issue | Vol 93, No. 2, 2016, pp.755-761
Published online, 30th November, 2015
DOI: 10.3987/COM-15-S(T)29
Synthesis of Hantzsch 1,4-Dihydropyridines in a Continuous Flow Microreactor

Peiyuan Gao, Xuan Sun, Ming Lei,* and Hong Zhang

*Department of Chemistry, Zhejiang University , 38 Zheda Road, Hangzhou, 310027, China

Abstract

A simple and efficient synthesis of Hantzsch 1,4-dihydropyridines from the condensation of benzaldehydes with alkyl acetoacetates/benzoylacetate and aqueous ammonia in the absence of catalyst has been developed by using a continuous flow microreactor. Under optimized condition, various 1,4-dihydropyridines were obtained in 80-93% yield with high atom efficiency. Compared with using batch system, the present smooth procedure greatly accelerated the reaction due to the excellent mixing and mass transfer of reactant in micro flow system.