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Short Paper | Regular issue | Vol 91, No. 9, 2015, pp.1775-1780
Published online, 4th August, 2015
DOI: 10.3987/COM-15-13266
Phenylpropanoids from the Leaves of Nicotiana tabacum and Their Anti-Tobacco Mosaic Virus Activities

Qin-Peng Shen, Lan Li, Xin-Meg Xu, Chun-Bo Liu, Neng-Jun Xiang, Feng-Mei Zhang, Pei He, Zhi-Hua Liu, Shan-Zhai Shang, Ming-Ming Miao,* and Guang-Yu Yang*

*Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industry Company, Hongjin Road 181#, Kunming, 650231, China

Abstract

Two new phenylpropanoids, 5-hydroxy-6-(3-hydroxypropanoyl)- isobenzofuran-1(3H)-one (1), 6-(3-hydroxypropanoyl)-5-methylisobenzofuran- 1(3H)-one (2), together with four known phenylpropanoids (3-6) were isolated from the leaves of Nicotiana tabacum. Their structures were determined by means of HRESIMS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1-5 were tested for their anti-tobacco mosaic virus (anti-TMV) activities. The results showed that Compound 2 showed high anti-TMV activity with inhibition rate of 29.2%. This rate is close to that of positive control. The other compounds also showed potential anti-TMV activity with inhibition rates in the ranges of 20.3-24.6%, respectively.