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Paper | Regular issue | Vol 91, No. 12, 2015, pp.2306-2314
Published online, 25th November, 2015
DOI: 10.3987/COM-15-13326
Highly Chemoselective Synthesis of Benzimidazoles in Sc(OTf)3-Catalyzed System

Liyan Fan,* Lulu Kong, and Wen Chen

*Department of Chemistry, Tongji University, Shanghai Siping Road 1239, China


The present researches elicit a simple, green and efficient method for the synthesis of substituted benzimidazoles through the coupling of o-phenylenediames with aldehydes catalyzed by Sc(OTf)3 in ethanol, which obtains high chemoselectivity and excellent yield of many biologically active 1,2-disubstitued and 2-substituted benzimidazoles respectively and are also environment friendly.