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Short Paper | Regular issue | Vol 91, No. 9, 2015, pp.1816-1822
Published online, 2nd September, 2015
DOI: 10.3987/COM-15-13287
Flavones from the Leaves of Yunnan Local Sun Cured Tobacco and Their Cytotoxicity

Yu-Ping Wu, Guang-Hui Kong, Wei Li, Neng-Jun Xiang, Li-Xuang Liu, Guo-Rong Yang, Xiu-Ping Lu,* and Qiang Liu*

*Yunnan Academy of Tobacco Agricultural Sciences, Kunming, Yunnan 650031, China

Abstract

Two new flavones, 4',7-dimethoxy-6-hydroxy-8-isobutyrylflavone (1), 4',7-dimethoxy-6-hydroxy-8-[(E)-3-hydroxy-2-methylprop-1-enyl]flavone (2), together with four known flavones (3-6) were isolated from the leaves of Yunnan local sun cured tobacco. Their structures were determined by means of HRESIMS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1-6 were screened for the cytotoxic activity in a panel of human cancer cell lines, including NB4, A549, SHSY5Y, PC3, and MCF7. Compound 2 exhibited high cytotoxicity for A549 and SHSY5Y cells with IC50 values of 1.6 and 2.8 μM, respectively. The other compounds also exhibited cytotoxicity with IC50 values in the range of 4.3 – 9.5 μM, respectively.