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Paper | Regular issue | Vol 91, No. 10, 2015, pp.1937-1954
Published online, 6th October, 2015
DOI: 10.3987/COM-15-13304
Synthesis, Characterization and Cytotoxicity Evaluation of Some Novel Pyrazole and Pyrrole Derivatives Containing Benzothiazole Moiety

Khaled S. Mohamed* and Ahmed A. Fadda

*Engineering Chemistry Department, Higher Institute for Engineering and Technology, New Damietta, New Damietta 34518, Egypt


The 1-(2-benzothiazolyl)-1-cyano-3-chloroacetone (1) was used as a key intermediate for the synthesis of pyrazole derivatives (3a-d) and pyrrole derivatives (5a-e) by its reaction with arylhydrazonomalononitrile and primary arylamines, respectively. Moreover, the reaction of 2-(benzo[d]thiazol-2-yl)-5-methyl-4-(pyridin-4-ylmethylene)-2,4-dihydro-3H-pyrazol-3-one (7) with a variety of reagents have been investigated aiming to explore its synthetic potentialities in synthesis of some novel pyrazole fused heterocyclic derivatives containing benzothiazole moiety. The structures of newly synthesized compounds have been established on the basis of their IR, 1H-NMR, 13C-NMR and mass spectral data. New compounds were tested for in vitro cytotoxicity against hepatocellular carcinoma (HepG-2) and breast cancer (MCF-7).