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Short Paper | Special issue | Vol 93, No. 2, 2016, pp.737-744
Published online, 16th November, 2015
DOI: 10.3987/COM-15-S(T)27
Synthesis of 2,3-Dihydro-4H-furo[3,2-c]chromen-4-one Derivatives by Oxidative Radical Cyclization of 4-Hydroxy-2H-chromen-2-one with Alkenes

Masahiro Yoshida,* Asuka Kobayashi, and Kosuke Namba

*Graduate School of Pharmaceutical Sciences, The University of Tokushima, Sho-machi, Tokushima 770-8505, Japan

Abstract

Oxidative radical cyclization of 4-hydroxy-2H-chromen-2-one with aryl-substituted alkenes has been developed. 2,3-Dihydro-4H-furo[3,2-c]chromen- 4-ones having substituents at the 2-position were produced when the reactions were carried out in the presence of CAN as an oxidant. Various substituted products were regioselectively synthesized via a successive cyclization.