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Paper | Regular issue | Vol 91, No. 12, 2015, pp.2285-2294
Published online, 24th November, 2015
DOI: 10.3987/COM-15-13322
Synthesis of 7-Desmethyl Analogs of (+)- and (−)-Huperzine A

Marco Pieroni* and Suresh K. Tipparaju

*Department of Pharmacy, University of Parma, Parco Area delle Scienze 27/a 43124, Italy

Abstract

The natural alkaloid (−)-huperzine A is an inhibitor of AChE and has been demonstrated to exert neuroprotection and to possess other CNS related properties. In this manuscript, we report the synthesis of the analogs of huperzine A, in their enantiomeric form, starting from a common precursor, that has the advantage of being easily prepared in both the enantiomeric forms, in high enantiomeric excess, and at moderate costs.