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Short Paper | Regular issue | Vol 91, No. 12, 2015, pp.2355-2366
Published online, 24th November, 2015
DOI: 10.3987/COM-15-13328
Phenolic Derivatives from the Stems of Lagerstroemia indica and Their Biological Activity

Kyeong Wan Woo, Won Se Suh, Lalita Subedi, Sun Yeou Kim, Sang Un Choi, Ki Hyun Kim, and Kang Ro Lee*

*Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 300 Chunchun-dong, Jangan-ku, Suwon 440-746, Korea

Abstract

The purification of a MeOH extract from the stems of Lagerstroemia indica (Lythraceae) using repeated column chromatography afforded three new phenolic glycosides (1-3), and a new flavone derivative (4) along with fifteen known compounds (5-19). The structures of new compounds were determined through spectral analysis, including 1D, 2D-NMR and MS data. Compounds 1-19 were evaluated for their inhibitory activities on nitric oxide (NO) production in an activated murine microglial cell line and cytotoxic activities against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15).