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Short Paper | Regular issue | Vol 91, No. 12, 2015, pp.2367-2376
Published online, 2nd December, 2015
DOI: 10.3987/COM-15-13340
Microwave-Assisted One-Pot Synthesis of N-Substituted 2-Methyl-1H-pyrrole-3-carboxylate Derivatives without Catalyst and Solvent

Wei Kan, Tao Jing, Xiao-hong Zhang, Yong-jie Zheng, Lin Chen, and Bing Zhao



An efficient one-pot synthetic method for the N-substituted 2-methyl-1H-pyrrole-3-carboxylate derivatives has been accomplished via a microwave irradiation MCRs of various α-bromoacetophenone, amines, and ethyl acetoacetate without any solvent and catalyst. This approach provides a convenient one pot method for the synthesis of N-substituted 2-methyl-1H-pyrrole-3-carboxylate derivatives.