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Short Paper | Regular issue | Vol 92, No. 3, 2016, pp.521-527
Published online, 5th February, 2016
DOI: 10.3987/COM-15-13368
■ Facile and Efficient Synthesis of 2-Aminoquinoline Derivatives Reduced by Zn/AcOH

Guolan Dou,* Deming Wang, and Daqing Shi

*School of Safety Engineering, China University of Mining & Technology, Xuzhou 221116, China

Abstract

In this paper, a simple and efficient method for one-pot synthesis of 2-aminoquinolines was accomplished in good yields via reductive cyclization of nitro and cyano groups mediated by zinc/acetic acid is reported.