HETEROCYCLES
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Short Paper | Regular issue | Vol 92, No. 9, 2016, pp.1655-1664
Published online, 26th July, 2016
Published online, 26th July, 2016
DOI: 10.3987/COM-15-13391
■ A Green, Solvent-Free One-Pot Synthesis of Disubstituted Quinolines via A3-Coupling Using 1 Mol% FeCl3
Shivani Naidoo and Vineet Jeena*
*School of Chemistry and Physics, University of KwaZulu-Natal, Cnr Golf and Ridge Roads 3209, South Africa
Abstract
A simple and green route towards disubstituted quinolines via A3-coupling using 1 mol% FeCl3 is described. Using this approach, the above-mentioned derivatives were synthesized in moderate to good yields (45-95%) under solvent-free, microwave conditions. Preliminary investigations have indicated that a further decrease in catalyst amount is possible with a satisfactory yield still observed.
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