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Paper | Regular issue | Vol 92, No. 6, 2016, pp.1075-1084
Published online, 8th April, 2016
DOI: 10.3987/COM-16-13451
Synthesis and Antimicrobial Evaluations of Novel Spiro Cyclic 2-Oxindole Derivatives of N-(1H-Pyrazol-5-Yl)-Hexahydroquinoline Derivatives

Said Ahmed Soliman Ghozlan, Muhammed Ali Ramadan, Amr Mohamed Abdelmoniem,* and Ismail Abdelshafy Abdelhamid*

*Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt


A novel series of interesting spiro cyclic 2-oxindole derivatives of N-(1H-pyrazol-5-yl)hexahydroquinoline derivatives were prepared via the versatile readily accessible cyclic β-enaminones incorporating pyrazole. Antimicrobial evaluations were performed on the prepared compounds. Most of these compounds exhibited high to moderate antimicrobial activity.