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Short Paper | Special issue | Vol 95, No. 1, 2017, pp.587-594
Published online, 16th September, 2016
DOI: 10.3987/COM-16-S(S)27
Synthesis of 4-Substituted-Pyridine-2,6-dicarboxylic Acid Derivatives from Pyruvates and Aldehydes in One Pot

Pandurang V. Chouthaiwale, Sébastien Lapointe, and Fujie Tanaka*

*Chemistry and Chemical Bioengineering Unit, Okinawa Institute of Science and Technology Graduate University, 1919-1 Tancha, Onna, Okinawa 904-0495, Japan


4-Substituted-pyridine-2,6-dicarboxylic acid derivatives were synthesized in one pot under mild conditions via the formation of dihydropyran derivatives from pyruvates and aldehydes catalyzed by pyrrolidine-acetic acid, followed by the reaction with ammonium acetate.