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Paper | Regular issue | Vol 92, No. 9, 2016, pp.1629-1642
Published online, 21st July, 2016
DOI: 10.3987/COM-16-13508
A Facile Preparation of Imidazo[1,2-a]pyridin-3-amine Derivatives via a Three-Component Reaction with β-Cyclodextrin–SO3H as Catalyst

Jian Wu,* Fang-Zhou Xu, She-Lei Feng, Wei Xue, and Zhen-Zhen Wang

*Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China

Abstract

Because heterogeneous catalysts have attracted great interest in organic chemistry, this paper reports facile β-cyclodextrin–SO3H–catalyzed cyclization to form imidazo[1,2-a]pyridin-3-amine derivatives via a three-component reaction. The main advantages of this strategy include short reaction time, practical simplicity, and high yield, and the catalyst can be separated easily by filtration and reused at least four times.