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Short Paper | Regular issue | Vol 92, No. 9, 2016, pp.1713-1720
Published online, 5th August, 2016
DOI: 10.3987/COM-16-13521
Three New Isoindolin-1-ones from the Leaves of Yunnan Local Sun Cured Tobacco and Their Bioactivities

Feng-Mei Zhang, Jian-Jun Xia, Pei-Song Yang, Qin-Peng Shen, Chun-Bo Liu, Pei He, Jia-Qiang Wang, Zhi-Hua Liu,* and Zhong-Tao Ding*

*Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industry Company, Hongjin Road 181#, Kunming, 650231, China

Abstract

Three new (1-3) and one known (4) isoindolin-1-ones were isolated from the leaves of Yunnan local sun cured tobacco. Their structures were determined by means of HRESIMS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1-3 were tested for their anti-tobacco mosaic virus (anti-TMV) activities and compounds 1-4 were tested for their cytotoxicity activities. The results showed that compounds 1-3 showed high anti-TMV activity with inhibition rates of 43.8, 45.6 and 52.7%. These rates are higher than that of positive control. Compounds 1-4 also showed moderate-to-weak inhibitory activities against some tested human tumor cell lines with IC50 values in the range of 2.8–8.2 μM.