HETEROCYCLES
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Obituary
Zenichi Yoshida (1925-2023)
Zenichi Yoshida (1925-2023)
Professor. Zenichi Yoshida,
a member of the Honorary Advisors of HETEROCYCLES (1975-1998),
has passed away on May 4, 2023 at the age of 97.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
May 11, 2023
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Review | Special issue | Vol 95, No. 2, 2017, pp.662-693
Published online, 16th January, 2017
Published online, 16th January, 2017
DOI: 10.3987/REV-16-SR(S)5
■ Synthesis of Caprazamycins and Related Natural Products
Takumi Watanabe*
*Institute of Microbial Chemistry, Tokyo (BIKAKEN), 3-14-23 Kamiosaki Shinagawa-ku, Tokyo 141-0021, Japan
Abstract
Caprazamycins are the lead compound for CPZEN-45, which exhibits activity against extensively drug resistant tuberculosis (XDR-TB) and is currently under preclinical studies. The development of an efficient synthetic route to caprazamycins and related compounds is expected to facilitate structure-activity relationship studies on anti-TB agents. This review summarizes current synthetic strategies for caprazamycins, liposidomycins, caprazol, and CPZEN-45, with a particular focus on stereocontrol and diazepanone ring formation.
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