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Short Paper | Regular issue | Vol 94, No. 2, 2017, pp.314-325
Published online, 25th January, 2017
DOI: 10.3987/COM-16-13611
A Multi-Component One-Pot Synthesis of Novel (1,3,4-Thiadiazin-2-ylamino)isoindoline-1,3-diones as Antimicrobial Agents

Rizk E. Khidre,* Bakr F. Abdel-Wahab, and Ghada E. A. Awad

*Chemistry Department, National Research Center Jazan University, KSA Cairo, Egypt


A series of new (1,3,4-thiadiazin-2-ylamino)isoindoline-1,3-dione derivatives 5, 8, 9, 11a-d, and 13a,b were prepared via one-pot three component reaction of isobenzofuran-1,3-dione 1, thiocarbohydrazide 2 and various α-halocarbonyl compounds. The chemical structure of the new compounds was elucidated by spectral analyses and X-ray single crystal technique. The newly synthesized compounds were also evaluated for their in vitro antimicrobial activity, and showed promising results.