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Paper | Regular issue | Vol 94, No. 2, 2017, pp.276-285
Published online, 27th January, 2017
DOI: 10.3987/COM-16-13623
One-Pot and Efficient Synthesis of 5-Aminopyrazole-4-carbonitriles Catalyzed by Potassium Phthalimide

Hamzeh Kiyani* and Maryam Bamdad

*School of Chemistry, Damghan University, Cheshmeh Ali Road, Daneshgah square, Damghan 36715-364, Iran


The potassium phthalimide (PPI) has been found to be an efficient, recyclable, inexpensive, commercially available, and easy to handle catalyst for the synthesis of 5-aminopyrazole-4-carbonitriles through the one-pot, three-component reaction of easily available starting reactants involving aldehydes, phenylhydrazine, and malononitrile. This reaction was performed in a mixture of EtOH:H2O as a green reaction media at 50 °C. The catalyst could be recovered easily from the filtrate via evaporation of solvent and reused many times. The present eco-friendly three-component cyclocondensation offers main benefits including, time-saving, mild conditions, minimize the amount of waste, high atom efficiency, avoiding the hazardous organic solvents or catalysts, and the ease of the work-up.