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Paper | Regular issue | Vol 94, No. 6, 2017, pp.1027-1039
Published online, 8th May, 2017
DOI: 10.3987/COM-17-13659
■ PEG-OSO3H as an Efficient Catalyst in the Synthesis of N3-Functionalized 3.4-Dihydropyrimidinone and Quinazolinone Derivatives

Liang-Jie Yang, Jin-Ge Luo, and Xi-Cun Wang*

*College of Chemistry and Chemical Engineering, Northwest Normal University, Anning East Road, 967, 730070, China

Abstract

PEG-OSO3H-catalyzed three-component reaction of 3,4-dihydropyrimidones and quinazolinone with paraformaldehyde and various reagents for synthesis of N3-functionalized 3,4-dihydropyrimidone and quinazolinone derivatives is described. 2-Hydroxy-substituted 3,4-dihydropyrimidone reacts with aldehydes giving benzo[e]pyrimido[1,6-c][1,3]oxazines. This paper explores the versatility and effectiveness of polymer bound sulfonic acids as catalysts in different C-N and C-O bonds formation reactions. The reactions were completed in short times, and the products were obtained in good to excellent yields. The catalysts activity and recyclability were investigated completely.