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Short Paper | Regular issue | Vol 94, No. 6, 2017, pp.1143-1151
Published online, 11th May, 2017
DOI: 10.3987/COM-17-13697
An Efficient and Multi-Component Synthesis of 5-Imino-3,5-dihydro-2H-chromeno[3,4-c]pyridin-2-one Derivatives

Juxian Wang, Yang Gao, Juanjuan Zhang, Guoning Zhang, Jinfeng Ren, Yue Zhao, Yucheng Wang,* and Daqing Shi*

*College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China

Abstract

A facile and efficient one-pot procedure for the synthesis of 5-imino-3,5-dihydro-2H-chromeno[3,4-c]pyridin-2-one derivatives via a four-component reaction of salicylaldehyde, malononitrile, ethyl cyanoacetate and hydrazine hydrate under mild conditions in excellent yield is described. The structures of fused molecules have been unambiguously confirmed by their spectroscopic techniques as well as by single crystal X-ray analysis.