Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 94, No. 6, 2017, pp.1074-1097
Published online, 22nd May, 2017
DOI: 10.3987/COM-17-13714
Synthesis and Biological Evaluation of Novel Di- and Trisubstituted Thiazole Derivatives

Irmantas Parašotas, Eglė Urbonavičiūtė, Kazimieras Anusevičius, Ingrida Tumosienė, Ilona Jonuškienė, Kristina Kantminienė,* Rita Vaickelionienė, and Vytautas Mickevičius

*Department of Physical and Inorganic Chemistry, Kaunas University of Technology, Radvilenu rd. 19, LT-50254 Kaunas, Lithuania


Novel di- and trisubstituted thiazole derivatives bearing heterocyclic, aromatic, chalcone, and carboxyalkyl-heterocyclic moieties were synthesized. Compounds possessing significant antibacterial activity, comparable to that of commercial antibacterial agent ampicillin, against Rhizobium radiobacter, Xanthomonas campestris, and Escherichia coli were identified. Some of the synthesized compounds exhibited a very high antioxidant activity.