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Short Paper | Regular issue | Vol 94, No. 9, 2017, pp.1766-1774
Published online, 13th July, 2017
DOI: 10.3987/COM-17-13758
■ Secalonic Acids H and I, Two New Secondary Metabolites from the Marine-Derived Fungus Penicillium oxalicum

Li Chen, Yan-Xue Bi, Ya-Ping Li, Xin-Xin Li, Qin-Ying Liu, Min-Gang Ying, Qiu-Hong Zheng, Lin Du,* and Qi-Qing Zhang*

*Institute for Natural Products Applications and Research Technologies, Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 73019, United States

Abstract

Two new secalonic acid derivatives, secalonic acids H and I (1 and 2), and one known compound, secalonic acid D (3), were isolated from the marine-derived fungus Penicillum oxalicum. The planar structures and relative configurations of the new compounds were elucidated by the analyses of their 1D and 2D NMR and high-resolution mass spectrometric data. The absolute configurations were established by comparison of their experimental and calculated electronic circular dichroism spectra. The in vitro cytotoxic activities of compounds 1 and 2 were evaluated against selected human cell lines.