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Short Paper | Regular issue | Vol 94, No. 11, 2017, pp.2095-2102
Published online, 22nd September, 2017
DOI: 10.3987/COM-17-13799
Three New C-Alkylated Flavones from the Flower of Rosa rugosa and Their Bioactivity

Jing Li, Huan-Huan Xing, Wei-Song Kong, Ye-Kun Yang, Lin Ye, Xin Liu, Yan-Ping Li, Gao-Xiong Rao, Hai-Ying Yang, Gang Du, Min Zhou, Qiu-Fen Hu, Guang-Yu Yang, Yun-Hua Qin,* and Xue-Mei Li*

*Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industry Company, Hongjin Road 181#, Kunming, 650231, China


Three new C-alkylated flavones (1-3), together with three known C-alkylated flavones (4-6), were isolated from the flower of Rosa rugosa. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D NMR techniques. Compounds 1-6 were evaluated for their anti-methicillin- resistant Staphylococcus aureus (anti-MRSA) activity. The results revealed that compound 1 showed good inhibition with inhibitaion zone diameter (IZD) of 13.4 ± 1.0 mm. Compounds 2-6 also showed weak inhibition with IZD in the range of 7.6 – 11.2 mm, respectively. Compounds 1-3 were also tested for the antioxidant activity, and they shows good antioxidant activity with an IC50 value of 4.2, 3.6 and 3.4 μg/mL, respectively.