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Communication | Special issue | Vol 97, No. 1, 2018, pp.141-146
Published online, 7th February, 2018
DOI: 10.3987/COM-17-S(T)15
Radical Cyclizations of Aryl Bromides for Synthesis of Cyclopenta[b]indoles from Vince Lactam

Takumi Abe,* Tsuyoshi Morita, and Koji Yamada

*Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293, Japan

Abstract

Radical cyclizations of aryl bromides, synthesized in two steps from Vince lactam, afforded cyclopenta[b]indoles in good yields. Furthermore, an unprecedented method for constructing cyclopenta[b]indoles utilizing tricyclic intermediate was also explored.