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Short Paper | Special issue | Vol 97, No. 2, 2018, pp.1210-1218
Published online, 17th April, 2018
DOI: 10.3987/COM-18-S(T)70
Towards New Sila- or Germa-Derivatives of Motesanib

Thomas Boddaert, Olivier Querolle, Lieven Meerpoel, Patrick Angibaud, Jacques Maddaluno, and Muriel Durandetti*

*COBRA UMR CNRS 6014, Normandie Univ, UNIROUEN, INSA Rouen, CNRS, 76000 Rouen, France


Developing new access to original silylated heterocycles is an emerging challenge in medicinal chemistry. In this paper, we describe a synthesis of silylated and germylated Motesanib analogues relying on a peptide coupling between a nicotinic acid derivative and silylated or germylated heterocycles, prepared according to our previous reports.