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Communication | Special issue | Vol 97, No. 1, 2018, pp.163-169
Published online, 23rd March, 2018
DOI: 10.3987/COM-18-S(T)33
2-Iodoimidazolinium Salt-Catalyzed Friedel–Crafts Reaction: Synthesis of Bis(indolyl)methane Alkaloids

Satoru Kuwano, Takumi Suzuki, and Takayoshi Arai*

*Department of Chemistry, Graduate School of Science, Chiba University, , Japan


2-Iodoimidazolinium salt-catalyzed Friedel–Crafts reactions of indoles with aldehydes were developed. Under mild reaction conditions, various bis(indolyl)methane derivatives, an important class of indole alkaloids, were obtained in good to high yields.