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Review | Regular issue | Vol 96, No. 5, 2018, pp.803-838
Published online, 19th April, 2018
DOI: 10.3987/REV-17-878
Rhodanine as a Scaffold: A Short Review on Its Synthesis and Anti-Diabetic Activities

Shaikha S. Alneyadi*

*Department of Chemistry, College of Science, UAE University, Al-Ain, UAE


Heterocyclic compounds play an important role in biological processes and synthetic medicinal chemistry, and comprise approximately half of the over 6 million compounds recorded to date in Chemical Abstracts. Owing to their high degree of structural variety, heterocycles have proven to be widely useful therapeutic agents and lead candidates in drug design. In this review, I outline recent studies on the synthesis of the rhodanine core, an important heterocyclic, and the anti-diabetic activities of its derivatives reported between 2007 and 2017.