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Paper | Special issue | Vol 97, No. 1, 2018, pp.355-364
Published online, 22nd February, 2018
DOI: 10.3987/COM-18-S(T)23
Phenylphosphinic Acid-Promoted Addition of Isocyanide to 1-Methoxyisochroman Derivatives

Takahiro Soeta,* Syunsuke Matsuzaki, and Yutaka Ukaji*

*Division of Material Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa, Ishikawa 920-1192, Japan

Abstract

A synthetic method for preparation of isochroman-1-carboxylamides in good to high yields by addition of isocyanides to 1-methoxyisochroman derivatives in the presence of phosphinic acid was developed. A wide range of 1-methoxyisochroman derivatives and isocyanides were suitable for this reaction.